منابع مشابه
Role of methotrexate polyglutamates in methotrexate- and sequential methotrexate-5-fluorouracil-mediated cell kill.
The synthesis of methotrexate (MTX) polyglutamates has been investigated in a human leukemia cell line, CCRF-CEM. An increase in either the extracellular MTX concentration (0.1-10 microM) or exposure time (4-24 h) allowed a greater accumulation of polyglutamate derivatives. The species which predominated (di-, tri-, or tetraglutamate) was also time and concentration dependent. Derivatives up to...
متن کاملMethotrexate and asthma.
population, 1)0th b()dV habitus and degree of effort expended in PEFR measurement var widely among patients. \Ve have found that percent predicted PEFRs are much more useful for the individual patient, both in assessing progress of therapy and in objectively comparing severity of respirator)’ distress with that on previous ED visits. Indeed, even the primary supporting study cited by the author...
متن کاملMeasuring methotrexate polyglutamates.
Methotrexate is the most commonly used drug in the treatment of rheumatoid arthritis, although 30-40% of patients fail to adequately respond. An accurate method for measuring methotrexate polyglutamates, the stable active metabolite of methotrexate, has recently been described. The objective of this review article is to determine if clinical use of this measurement would improve methotrexate ef...
متن کاملMethotrexate use and alcohol.
A literature review was performed to look at the interactions between alcohol and methotrexate in non-malignant disease. The evidence from research into psoriasis and inflammatory arthritis, and an overview of international and national guidelines, was amalgamated into some consensus recommendations.
متن کاملMethotrexate induced accelerated nodulosis.
Methotrexate induced accelerated nodulosis (MIAN) is a rare but unique side effect of methotrexate therapy. There is paucity of data from our country about this entity. We analyzed 14 cases of MIAN and studied its association with gender, rheumatoid factor positivity and dose and duration of methotrexate. Fourteen patients (8 females), 12 with rheumatoid arthritis (8 seropositive), one each wit...
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ژورنال
عنوان ژورنال: Reactions Weekly
سال: 2021
ISSN: ['1179-2051', '0114-9954']
DOI: https://doi.org/10.1007/s40278-021-95162-2